期刊
NATURE ECOLOGY & EVOLUTION
卷 2, 期 9, 页码 1479-1491出版社
NATURE PORTFOLIO
DOI: 10.1038/s41559-018-0611-6
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资金
- National Institutes of Health grant [GM120782]
- USDA Federal Hatch Project [538922]
- Russian Science Foundation [16-14-10009, 16-14-10216]
- Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences [0324-2018-0016]
- Campus Research Board
- Office of International Programs of the University of Illinois at Urbana-Champaign
- Strategic Priority Research Program of the Chinese Academy of Sciences [XDB13000000]
- Lundbeck fellowship [R190-2014-2827]
- Carlsberg Foundation grant [CF16-0663]
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM120782] Funding Source: NIH RePORTER
Strains of red fox (Vulpes vulpes) with markedly different behavioural phenotypes have been developed in the famous long-term selective breeding programme known as the Russian farm-fox experiment. Here we sequenced and assembled the red fox genome and re-sequenced a subset of foxes from the tame, aggressive and conventional farm-bred populations to identify genomic regions associated with the response to selection for behaviour. Analysis of the re-sequenced genomes identified 103 regions with either significantly decreased heterozygosity in one of the three populations or increased divergence between the populations. A strong positional candidate gene for tame behaviour was highlighted: SorCS1, which encodes the main trafficking protein for AMPA glutamate receptors and neurexins and suggests a role for synaptic plasticity in fox domestication. Other regions identified as likely to have been under selection in foxes include genes implicated in human neurological disorders, mouse behaviour and dog domestication. The fox represents a powerful model for the genetic analysis of affiliative and aggressive behaviours that can benefit genetic studies of behaviour in dogs and other mammals, including humans.
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