期刊
FRONTIERS IN PEDIATRICS
卷 3, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fped.2015.00054
关键词
glycosylation; congenital disorders of glycosylation; immunodeficiency; allergy; infection susceptibility
类别
资金
- Intramural Research Program of the National Institutes of Health (NIH) Clinical Center
- National Institutes of Allergy and Infectious Diseases (NIAID)
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [ZIAAI001183, ZIAAI001192, ZIAAI001122, ZIAAI001098] Funding Source: NIH RePORTER
Protein glycosylation is an important epigenetic modifying process affecting expression, localization, and function of numerous proteins required for normal immune function. Recessive germline mutations in genes responsible for protein glycosylation processes result in congenital disorders of glycosylation and can have profound immunologic consequences. Genetic mutations in immune signaling pathways that affect glycosylation sites have also been shown to cause disease. Sugar supplementation and in vivo alteration of glycans by medication holds therapeutic promise for some of these disorders. Further understanding of how changes in glycosylation alter immunity may provide novel treatment approaches for allergic disease, immune dysregulation, and immunodeficiency in the future.
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