期刊
IMMUNE NETWORK
卷 18, 期 4, 页码 -出版社
KOREA ASSOC IMMUNOLOGISTS
DOI: 10.4110/in.2018.18.e27
关键词
Damage-associated molecular patterns; Inflammation; Pattern recognition receptors; Inflammatory diseases
类别
资金
- Pusan National University
Damage-associated molecular patterns (DAMPs) are endogenous danger molecules that are released from damaged or dying cells and activate the innate immune system by interacting with pattern recognition receptors (PRRs). Although DAMPs contribute to the host's defense, they promote pathological inflammatory responses. Recent studies have suggested that various DAMPs, such as high-mobility group box 1 (HMGB1), S100 proteins, and heat shock proteins (HSPs), are increased and considered to have a pathogenic role in inflammatory diseases. Here, we review current research on the role of DAMPs in inflammatory diseases, including rheumatoid arthritis, systemic lupus erythematosus, osteoarthritis, atherosclerosis, Alzheimer's disease, Parkinson's disease, and cancer. We also discuss the possibility of DAMPs as biomarkers and therapeutic targets for these diseases.
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