期刊
ADIPOCYTE
卷 2, 期 4, 页码 217-226出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/adip.24953
关键词
adipocyte; fat cell size; adiponectin; high molecular weight; insulin resistance; adipose tissue depots; subcutaneous adipose tissue; visceral adipose tissue
资金
- UCLA/UCSD DERC [P30 DK063491]
- Department of Veterans Affairs Medical Research Service [P30 DK063491]
- Distinguished Clinical Scientist Award from the American Diabetes Association
Adiponectin is an insulin-sensitizing fat cell (FC) hormone whose levels are related to adipose tissue (AT) mass and depot distribution. We hypothesized that the nature of AT expansion (hypertrophy vs. hyperplasia) contributes to obesity-related reductions in serum adiponectin and that this effect is influenced by the regional distribution of AT to subcutaneous (S) and visceral (V) depots. Thirteen obese subjects provided paired AT biopsies. Serum total and high molecular weight (HMW) adiponectin levels were determined by ELISA. Secretion was quantified following 24 h explant culture. FC size, number, % large, and % small FC were determined by microscopic analysis. Secretion of total adiponectin was highest by SAT (P = 0.008) and correlated more strongly with serum adiponectin (total: P = 0.015, r = 0.77; HMW: P = 0.005, r = 0.83) than did secretion by VAT (P = 0.05, r = 0.66 for both). FC size was greatest in SA T and correlated negatively with both serum (total: P = 0.01, r = - 0.74; HMW: P = 0.03, r = - 0.69) and secreted (total: P = 0.05, r = - 0.72; HMW: P = 0.02, r = - 0.87) adiponectin. The % small FC in SA T correlated positively with both serum (total: P = 0.006, r = 0.87; HMW: P = 0.009, r = 0.79) and secreted (total: P = 0.03, r = 0.75; HMW: P = 0.01, r = 0.92) adiponectin. VAT FC size correlated negatively with serum HMW adiponectin (P = 0.01, r = - 0.76) but not with any measure of secretion. VAT had the greatest % small FC, which related positively to serum HMW (P = 0.004, r = 0.81) and to secreted total adiponectin (P = 0.02, r = 0.78). These studies indicate that differences in fat cell size and depot distribution of AT expansion are important influences on adiponectin in obesity.
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