期刊
ADIPOCYTE
卷 1, 期 3, 页码 182-187出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/adip.20787
关键词
Angptl4; glucocorticoids; fasting; lipolysis; adipocyte; cAMP; catecholamine
资金
- NIHR01 [DK83591]
- NIH Career Development Grant [5K08DK080174]
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [K08DK080174, R01DK083591] Funding Source: NIH RePORTER
Angiopoietin-like 4 (Angptl4) is a secreted protein modulating triacylglycerol homeostasis. Its transcription is induced by glucocorticoids, which act to elevate circulating Angptl4 levels during fasting. In investigating the role of Angptl4 in glucocorticoid action, we identified that in addition to its known ability to inhibit lipoprotein lipase, Angptl4 stimulates intracellular adipocyte lipolysis. Fatty acid release by murine adipocytes following fasting or treatment with glucocorticoids or catecholamines is highly Angptl4-dependent. In fact, Angptl4 can directly stimulate cAMPdependent PKA signaling and lipolysis when added to adipocytes. Here, we detail this novel Angptl4-dependent lipolytic regulatory mechanism and discuss its physiological and therapeutic implications.
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