期刊
ADIPOCYTE
卷 1, 期 4, 页码 200-202出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/adip.20877
关键词
myokine; myonectin; skeletal muscle; energy balance; CTRP15; lipid uptake; fatty acids; FATP; FABP
资金
- National Institutes of Health [DK084171]
- American Heart Association [SDG2260721]
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK084171] Funding Source: NIH RePORTER
The integrated control of animal physiology requires intimate tissue crosstalk, a vital task mediated by circulating humoral factors. As one type of these factors, adipose tissue-derived adipokines have recently garnered attention as important regulators of systemic insulin sensitivity and metabolic homeostasis. However, the realization that skeletal muscle also secretes a variety of biologically and metabolically active polypeptide factors (collectively called myokines) has provided a new conceptual framework to understand the critical role skeletal muscle plays in coordinating whole-body energy balance. Here, we highlight recent progress made in the myokine field and discuss possible roles of myonectin, which we have recently identified as a potential postprandial signal derived from skeletal muscle to integrate metabolic processes in other tissues, such as adipose and liver; one of its roles is to promote fatty acid uptake into cells. Myonectin is also likely an important mediator in inter-tissue crosstalk.
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