期刊
WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
卷 5, 期 5, 页码 97-101出版社
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.4251/wjgo.v5.i5.97
关键词
Genes; RAS; Colorectal neoplasms; Therapeutics; Mitogen-activated protein kinase signaling system
Two of the main cellular pathways in which the RAS protein operates are the mitogen-activated protein kinases (MAPK) and phosphoinositide-3 kinase (PI3K) pathways. In a normal cell, these are important in controlling several functions, such as cell growth and survival. It becomes self-evident that these events will be disrupted in a malignant cell with a deregulated MAPK or PI3K pathway. Mutations in genes involved in these pathways and interacting with RAS, as well as RAS itself will be discussed. The second part of this review concentrates on how crucial RAS signaling is in colorectal cancer progression, with references to treatment response and prognosis when RAS or other related mutations are present. (C) 2013 Baishideng. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据