期刊
KIDNEY INTERNATIONAL SUPPLEMENTS
卷 4, 期 1, 页码 75-78出版社
ELSEVIER SCIENCE INC
DOI: 10.1038/kisup.2014.14
关键词
aging; angiotensin; glomerulosclerosis; PPAR gamma; stem cells
资金
- NIDDK [P50 DK44757, DK56942, DK39261]
- Takeda Pharmaceutical Company
- Major State Basic Research Development Program of China [2012CB517700]
- Guangdong Medical Association
Glomerulosclerosis and interstitial fibrosis increase in the aging kidney, and glomerular filtration rate (GFR) decreases with increasing age. Decreases in stem cell number and function contribute to renal aging. High-dose angiotensin receptor blocker (ARB) not only slows the progression of glomerular and vascular sclerosis in aging but can also induce regression of these processes independently of its hemodynamic actions. By using new interventions, such as peroxisome proliferator activator receptor gamma (PPAR gamma) agonist, we can manipulate the process of renal aging by regulating stem cells and other mechanisms.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据