期刊
KIDNEY INTERNATIONAL SUPPLEMENTS
卷 4, 期 1, 页码 70-74出版社
ELSEVIER SCIENCE INC
DOI: 10.1038/kisup.2014.13
关键词
EGER; fibrosis; kidney; renal epithelial cells; transforming growth factor-beta 1
资金
- National Institutes of Health [DK-085065]
- National Nature Science Foundation of China [81270778, 81470920, 81200492, 81470991]
- Shanghai Pujiang Talent Foundation of China [13PJ1406900]
- Pudong New District Foundation of China [PWZxk2014-06]
- Major State Basic Research Development Program of China [2012CB517700]
- Guangdong Medical Association
Signaling through the epidermal growth factor receptor (EGFR) is involved in regulation of multiple biological processes, including proliferation, metabolism, differentiation, and survival. Owing to its aberrant expression in a variety of malignant tumors, EGFR has been recognized as a target in anticancer therapy. Increasingly, evidence from animal studies indicates that EGFR signaling is also implicated in the development and progression of renal fibrosis. The therapeutic value of EGFR inhibition has not yet been evaluated in human kidney disease. In this article, we summarize recent research into the role of EGFR signaling in renal fibrogenesis, discuss the mechanism by which EGFR regulates this process, and consider the potential of EGFR as an antifibrotic target.
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