Engineering of DNA templated tri-functional nano-chain of Fecore-Aushell and a preliminary study for cancer cell labeling and treatment

Here DNA has been used as templating and self-assembling reagent to grow the chain like nanostructure. We have designed the composite in such a fashion that we obtained optical and magnetic properties together in a single biological material. Optical properties characterized by UV-visible absorption, Circular Dichroism (CD) and their analysis show no denaturization of DNA. Transmission electron micrographs (TEM) indicate formation of chain like structure of the nanoparticles. Particles were functionalized with folic acid for labeling and treatment of cancer cell. (C) 2012 Cairo University. Production and hosting by Elsevier B.V. All rights reserved.