期刊
FRONTIERS IN ONCOLOGY
卷 8, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fonc.2018.00404
关键词
nanoparticles; physicochemical properties; DC targeting; cancer immunotherapy; DC functions
类别
资金
- National Natural Science Foundation of China [21677090, 91543204, 91643204]
- National Key Research and Development Program of China [2016YFA0203103]
- Strategic Priority Research Program of the Chinese Academy of Sciences [XDB14030401]
- China Postdoctoral Science Foundation [2016T90634]
- Science Starting Foundation of Guangzhou University [69-18ZX10332]
Dendritic cells (DCs) are the primary antigen-presenting cells and play key roles in the orchestration of the innate and adaptive immune system. Targeting DCs by nanotechnology stands as a promising strategy for cancer immunotherapy. The physicochemical properties of nanoparticles (NPs) influence their interactions with DCs, thus altering the immune outcome of DCs by changing their functions in the processes of maturation, homing, antigen processing and antigen presentation. In this review, we summarize the recent progress in targeting DCs using NPs as a drug delivery carrier in cancer immunotherapy, the recognition of NPs by DCs, and the ways the physicochemical properties of NPs affect DCs' functions. Finally, the molecular pathways in DCs that are affected by NPs are also discussed.
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