期刊
FRONTIERS IN ONCOLOGY
卷 8, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fonc.2018.00311
关键词
lung cancer; NSCLC; SCLC; Circulating tumor cells; liquid biopsy
类别
资金
- Queensland Centre for Head and Neck - Atlantic Philanthropies
- Queensland Government
- Translational Research Institute (TRI) Spore grant
- QUT VC Fellowship
- QUT postgraduate research scholarship
Lung cancer affects over 1.8 million people worldwide and is the leading cause of cancer related mortality globally. Currently, diagnosis of lung cancer involves a combination of imaging and invasive biopsies to confirm histopathology. Non-invasive diagnostic techniques under investigation include liquid biopsies through a simple blood draw to develop predictive and prognostic biomarkers. A better understanding of circulating tumor cell (CTC) dissemination mechanisms offers promising potential for the development of techniques to assist in the diagnosis of lung cancer. Enumeration and characterization of CTCs has the potential to act as a prognostic biomarker and to identify novel drug targets for a precision medicine approach to lung cancer care. This review will focus on the current status of CTCs and their potential diagnostic and prognostic utility in this setting.
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