期刊
FRONTIERS IN ONCOLOGY
卷 3, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fonc.2013.00135
关键词
epigenetics; DNA methylation; hypomethylating agent; histone deacetylase inhibitors; microRNAs; lung cancer
类别
资金
- National Cancer Institute [P3OCA014089]
- NATIONAL CANCER INSTITUTE [P30CA014089] Funding Source: NIH RePORTER
Epigenetic deregulation of gene function has been strongly implicated in carcinogenesis and is one of the mechanisms contributing to the development of lung cancer. The inherent reversibility of epigenetic alterations makes them viable therapeutic targets. Here, we review the therapeutic implications of epigenetic changes in lung cancer, and recent advances in therapeutic strategies targeting DNA methylation and histone acetylation.
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