期刊
FRONTIERS IN ONCOLOGY
卷 2, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fonc.2012.00026
关键词
ubiquitin ligases; deubiquitinating enzymes; DUBs; H2Aub; H2Bub; BRCA1; RNF20; USP22
类别
资金
- V Scholar Award
- Breast Cancer Alliance Young Investigator Grant
- Melanoma Research Foundation Career Development Award
- Alexander and Margaret Stewart Trust Fellowship
- Yale Center for Clinical Investigation
- Yale Comprehensive Cancer Center
- NIH [CA16359]
- National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH) [UL1 RR024139]
Histone post-transcriptional modifications play essential roles in regulation of all DNA related processes. Among them, histone ubiquitination has been discovered for more than three decades. However, its functions are still less well understood than other histone modifications such as methylation and acetylation. In this review, we will summarize our current understanding of histone ubiquitination and deubiquitination. In particular, we will focus on how they are regulated by histone ubiquitin ligases and deubiquitinating enzymes. We will then discuss the roles of histone ubiquitination in transcription and DNA damage response and the crosstalk between histone ubiquitination and other histone modifications. Finally, we will review the important roles of histone ubiquitination in stem cell biology and cancer.
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