Autoantibodies to Tailor-Made Panels of Tumor-Associated Antigens in Breast Carcinoma

Autoantibodies (AAbs) to tumor-associated antigens (TAAs) have been identified in the sera of cancer patients. In a previous review published in this journal, we have focused on recent knowledge related to circulating AAbs to individual TAAs in breast carcinoma. This review will focus on recent knowledge related to AAb assays to tailor- made panels of TAAs in breast carcinoma. So far, AAb assays to the following tailor- made panels of TAAs have been assessed in breast carcinoma: (1)p53, c-myc, HER2, NYESO-1, BRCA2, and MUC1, (2)IMP1,p62, Koc, p53, c-MYC, cyclin B1, and survivin, (3)PPIA, PRDX2, FKBP52, HSP-60, and MUC1, (4) MUC1, HER2, p53, and IGFBP2, (5) p53, HER2,IGFBP-2, and TOPO2a, (6) survivin and livin, (7)ASB-9, SERAC1, and RELT, and (8)p16, p53, and c-myc. Assessment of serum AAbs to a tailor- made panel of TAAs provides better sensitivity to diagnosis of breast carcinoma than measuring serum AAbs to a single TAA. Nevertheless, measurement of serum AAbs to a panel of TAAs for screening and early diagnosis of breast carcinoma is still investigational and should be carried out along with traditional diagnostic studies.