期刊
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
卷 9, 期 1, 页码 42-49出版社
HONG KONG ASIAMED PUBLISH HOUSE
DOI: 10.1016/j.ajps.2013.11.007
关键词
Paclitaxel; Glassy carbon electrode; Voltammetry; Injection analysis; Urine
资金
- UGC, New Delhi
The electrochemical behavior of paclitaxel drug was studied at a glassy carbon electrode in phosphate buffer solutions using cyclic and differential-pulse voltammetric techniques. The oxidation process was shown to be irreversible over the pH range (3.0-10.4) and was diffusion controlled. Effects of anodic peak potential (E-p), anodic peak current (I-pa), scan rate, pH, heterogeneous rate constant (k(0)), etc have been discussed. A possible electro-oxidation mechanism was proposed. An analytical method was developed for the determination of paclitaxel in phosphate buffer solution at pH = 7.0 as a supporting electrolyte. The anodic peak current varied linearly with paclitaxel concentration in the range 1.0 x 10(-6) M to 1.0 x 10(-5) M with a limit of detection (LOD) of 1.23 x 10(-8) M and limit of quantification (LOQ) of 4.10 x 10(-8) M. The proposed method was successfully applied to the determination of paclitaxel in pure and real samples. (C) 2013 Shenyang Pharmaceutical University. Production and hosting by Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据