期刊
CELLS
卷 7, 期 9, 页码 -出版社
MDPI
DOI: 10.3390/cells7090128
关键词
protein secretion; Saccharomyces cerevisiae; unconventional secretion pathway; fungal allergens
类别
资金
- JST CREST [JPMJCR16G2]
Development of proteome analysis of extracellular proteins has revealed that a wide variety of proteins, including fungal allergens are present outside the cell. These secreted allergens often do not contain known secretion signal sequences. Recent research progress shows that some fungal allergens are secreted by unconventional secretion pathways, including autophagy- and extracellular-vesicle-dependent pathways. However, secretion pathways remain unknown for the majority of extracellular proteins. This review summarizes recent data on unconventional protein secretion in Saccharomyces cerevisiae and other fungi. Particularly, methods for evaluating unconventional protein secretion are proposed for fungal species, including S. cerevisiae, a popular model organism for investigating protein secretion pathways.
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