期刊
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
卷 465, 期 3, 页码 374-380出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2015.08.007
关键词
Wnt/beta-catenin; MiR-30a-5p; NCAM; Cell invasion
资金
- National Natural Science Foundation of China [81172400, 81272799, 81401500]
- Scientific and Technological Development Program of Suzhou, China [SYS201477, SYSD2012090]
- University Natural Science Foundation of Jiangsu, China [15KJB320011]
- Priority Academic Program Development of Jiangsu Higher Education Institutions, China
Wnt/beta-catenin signaling pathway is frequently dysregulated in human tumors and plays a critical role in tumorigenesis; however, the roles of microRNAs in mediating Wnt/b-catenin pathway are not well understood. Herein, we show that miR-30a-5p is activated by Wnt/beta-catenin pathway through direct binding of beta-catenin/TCF4 to two sites in the promoter region of miR-30a-5p. We also found that miR-30a-5p represses neural cell adhesion molecule (NCAM) expression by directly targeting two sites in the 3' untranslated region (3'-UTR) of NCAM mRNA. Moreover, Wnt/beta-catenin pathway represses NCAM expression in glioma cells, which depends on miR-30a-5p. Finally, we found that miR-30a-5p promotes glioma cell growth invasion by repressing NCAM. Our findings demonstrate a novel Wnt/beta-catenin-miR-30a-5p NCAM regulatory axis which plays important roles in controlling glioma cell invasion and tumorigenesis. (C) 2015 Elsevier Inc. All rights reserved.
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