期刊
CANCERS
卷 10, 期 8, 页码 -出版社
MDPI
DOI: 10.3390/cancers10080242
关键词
epithelial ovarian cancer; tumor microenvironment; tumor infiltrating lymphocytes; tumor-associated antigens; ascites; immunosuppression; prognostic factors; cancer-associated fibroblasts; exosomes; adipocytes
类别
资金
- BioCanRx
- Canadian Institutes of Health Research
- Fonds de recherche du Quebec-Sante
- Vanier Canada Graduate Scholarship
Immunotherapy as a treatment for cancer is a growing field of endeavor but reports of success have been limited for epithelial ovarian cancer. Overcoming the challenges to developing more effective therapeutic approaches lies in a better understanding of the factors in cancer cells and the surrounding tumor microenvironment that limit response to immunotherapies. This article provides an overview of some ovarian cancer cell features such as tumor-associated antigens, ovarian cancer-derived exosomes, tumor mutational burden and overexpression of immunoinhibitory molecules. Moreover, we describe relevant cell types found in epithelial ovarian tumors including immune cells (T and B lymphocytes, Tregs, NK cells, TAMs, MDSCs) and other components found in the tumor microenvironment including fibroblasts and the adipocytes in the omentum. We focus on how those components may influence responses to standard treatments or immunotherapies.
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