期刊
ACTA NEUROPATHOLOGICA COMMUNICATIONS
卷 2, 期 -, 页码 -出版社
BMC
DOI: 10.1186/s40478-014-0163-1
关键词
Regulatory T cells; 2-photon imaging; Experimental autoimmune encephalomyelitis
资金
- Hertie foundation (Deutsche Forschungsgemeinschaft) [SFB/CRC 128]
- KKNMS (Klinische Kompetenznetz Multiple Sklerose
- BMBF)
- Max Planck Society
- Hertie senior professorship
- Novartis Foundation for Therapeutic Research and LMU Munich
Regulatory T cells are crucial in controlling various functions of effector T cells during experimental autoimmune encephalomyelitis. While regulatory T cells are reported to exert their immunomodulatory effects in the peripheral immune organs, their role within the central nervous system (CNS) during experimental autoimmune encephalomyelitis is unclear. Here, by combining a selectively timed regulatory T cells depletion with 2-photon microscopy, we report that regulatory T cells exercise their dynamic control over effector T cells in the CNS. Acute depletion of regulatory T cells exacerbated experimental autoimmune encephalomyelitis severity which was accompanied by increased pro-inflammatory cytokine production and proliferation of effector T cells. Intravital microscopy revealed that, in the absence of regulatory T cells, the velocity of effector T cells was decreased with simultaneous increase in the proportion of stationary phase cells in the CNS. Based on these data, we conclude that regulatory T cells mediate recovery from experimental autoimmune encephalomyelitis by controlling cytokine production, proliferation and motility of effector T cells in the CNS.
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