期刊
TRANSLATIONAL NEURODEGENERATION
卷 1, 期 -, 页码 -出版社
BIOMED CENTRAL LTD
DOI: 10.1186/2047-9158-1-14
关键词
Neurotrophin; Neurotrophic factor; BDNF; NGF; Gene delivery; Mimetics
资金
- NIH Neuroplasticity of Aging Predoctoral Training Grant
- UCSD NIH ADRC Pilot Grant
- LLHF
- DSRTF
Neurotrophic factors are best known for their roles in both development and continued maintenance of the nervous system. Their strong potential to elicit pro-survival and pro-functional responses in neurons of the peripheral and central nervous system make them good drug candidates for treatment of a multitude of neurodegenerative disorders. However, significant obstacles remain and need to be overcome before translating the potential of neurotrophins into the therapeutic arena. This article addresses current efforts and advances in resolving these challenges and provides an overview of roadmaps for future translational research and neurotrophin-based drug developments.
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