期刊
ACTA PHARMACEUTICA SINICA B
卷 4, 期 1, 页码 18-25出版社
INST MATERIA MEDICA, CHINESE ACAD MEDICAL SCIENCES
DOI: 10.1016/j.apsb.2013.11.001
关键词
Solid dispersion; Poorly soluble drug; Phase separation; Drug-polymer interaction
资金
- National Natural Science Foundation of China [50873056]
The solid dispersion has become an established solubilization technology for poorly water soluble drugs. Since a solid dispersion is basically a drug-polymer two-component system, the drug-polymer interaction is the determining factor in its design and performance. In this review, we summarize our current understanding of solid dispersions both in the solid state and in dissolution, emphasizing the fundamental aspects of this important technology. (C) 2014 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.
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