期刊
EBIOMEDICINE
卷 34, 期 -, 页码 267-274出版社
ELSEVIER
DOI: 10.1016/j.ebiom.2018.07.036
关键词
Circular RNA; Biomarker; Diseases; Liquid biopsy
资金
- National Natural Science Foundation of China [81722008, 91639101, 81570362]
- Innovation Program of Shanghai Municipal Education Commission [2017-01-07-00-09-E00042]
- Science and Technology Commission of Shanghai Municipality [17010500100]
- development fund for Shanghai talents
Circular RNA (circRNA) is a group of endogenous noncoding RNA characterized by a covalently closed cyclic structure lacking poly-adenylated tails. Recent studies have suggested that circRNAs play a crucial role in regulating gene expression by acting as a microRNA sponge, RNA binding protein sponge and translational regulator. CircRNAs have become a research hotspot because of their close association with the development of diseases. Some circRNAs are reportedly expressed in a tissue-and development stage-specific manner. Furthermore, due to other features of circRNAs including stability, conservation and high abundance in body fluids, circRNAs are believed to be potential biomarkers for various diseases. In the present review, we provide the current understanding of biogenesis and gene regulatory mechanisms of circRNAs, summarize the recent studies on circRNAs as potential diagnostic and prognostic biomarkers, and highlight the major advantages and limitations of circRNAs as novel biomarkers based on existing knowledge. (c) 2018 The Authors. Published by Elsevier B.V.
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