期刊
SCIENCE ADVANCES
卷 4, 期 8, 页码 -出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/sciadv.aau1291
关键词
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资金
- Marie Curie Intra-European Fellowship for Career Development [625372]
- Whitaker International Scholar grant
- European Research Council under the European Union's Horizon 2020 Research and Innovation Programme [716867]
- Excellence Initiative of Aix-Marseille University (A*MIDEX), a French Investissements d'Avenir programme
- A*MIDEX project MIDOE [A_M-AAP-ID-13-24-130531-16.31-BERNARD-HLS]
- European Research Council (ERC) [716867] Funding Source: European Research Council (ERC)
The persistence of intractable neurological disorders necessitates novel therapeutic solutions. We demonstrate the utility of direct in situ electrophoretic drug delivery to treat neurological disorders. We present a neural probe incorporating a microfluidic ion pump (mu FIP) for on-demand drug delivery and electrodes for recording local neural activity. The mu FIP works by electrophoretically pumping ions across an ion exchange membrane and thereby delivers only the drug of interest and not the solvent. This dry delivery enables precise drug release into the brain region with negligible local pressure increase. The therapeutic potential of the mu FIP probe is tested in a rodent model of epilepsy. The mu FIP probe can detect pathological activity and then intervene to stop seizures by delivering inhibitory neurotransmitters directly to the seizure source. We anticipate that further tailored engineering of the mu FIP platform will enable additional applications in neural interfacing and the treatment of neurological disorders.
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