期刊
ACS BIOMATERIALS SCIENCE & ENGINEERING
卷 1, 期 12, 页码 1250-1255出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsbiomaterials.5b00274
关键词
mesoporous silica nanoparticle; drug delivery; isoniazid; trehalose
资金
- National Institutes of Health [R01GM080295, R21AI109896]
- China Scholarship Council
Glyconanoparticle carriers have been synthesized and efficiently delivered into mycobacteria. Mesoporous silica nanoparticles were functionalized with a,a-trehalose through azide-mediated surface photoligation, and loaded with the antitubercular drug isoniazid. The glyconanoparticles showed high isoniazid loading capacity and higher antimicrobial activity than the free drug.
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