期刊
FRONTIERS IN PEDIATRICS
卷 2, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fped.2014.00007
关键词
pulmonary arterial hypertension; pediatric; biomarkers; imaging; magnetic resonance; echocardiography; right ventricle
类别
资金
- NCATS NIH HHS [UL1 TR001082] Funding Source: Medline
- NHLBI NIH HHS [R01 HL114887] Funding Source: Medline
Therapeutic approaches in pediatric pulmonary arterial hypertension (PAH) are based primarily on clinician experience, in contrast to the evidence-based approach in adults with pulmonary hypertension. There is a clear and present need for non-invasive and objective biomarkers to guide the accurate diagnosis, treatment, and prognosis of this disease in children. The multifaceted spectrum of disease, clinical presentation, and association with other diseases makes this a formidable challenge. However, as more progress is being made in the understanding and management of adult PAH, the potential to apply this knowledge to children has never been greater. This review explores the state of the art with regard to non-invasive biomarkers in PAH, with an eye toward those adult PAH biomarkers potentially suitable for application in pediatric PAH.
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