期刊
FRONTIERS IN PSYCHIATRY
卷 6, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fpsyt.2015.00034
关键词
psychomotor performance; major depressive disorder; neuroimaging; frontal lobe; basal ganglia; monoamines
类别
资金
- Svenska Lakaresallskapet (The Swedish Society of Medicine) [SLS-403101]
- Strategic Research Committee, Karolinska Institutet/Stockholm County Council, Sweden
- Schizofreniforbundet, Sweden
Psychomotor disturbances (PMD) are a classic feature of depressive disorder that provides rich clinical information. The aim our narrative review was to characterize the functional anatomy of PMD by summarizing findings from neuroimaging studies. We found evidence across several neuroimaging modalities that suggest involvement of fronto-striatal neurocircuitry, and monoaminergic pathways and metabolism. We suggest that PMD in major depressive disorder emerge from an alteration of limbic signals, which influence emotion, volition, higher-order cognitive functions, and movement.
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