期刊
FRONTIERS IN ENDOCRINOLOGY
卷 6, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fendo.2015.00070
关键词
regeneration; adrenal cortex; stem cells; transplantation; encapsulation; steroidogenesis; zonation; SF1
资金
- Biotechnology and Biological Sciences Research Council (BBSRC) [BB/L00267/1]
- Rosetrees Trust
- Barts and The London Charity [417/2235]
- EU COFUND [PCOFUND-GA-2013-608765]
- Medical Research Council (MRC) [G0802796]
- Biotechnology and Biological Sciences Research Council [BB/L002671/1] Funding Source: researchfish
- Medical Research Council [1504803] Funding Source: researchfish
- Rosetrees Trust [M355] Funding Source: researchfish
- BBSRC [BB/L002671/1] Funding Source: UKRI
Adrenal disease, whether primary, caused by defects in the hypothalamic-pituitary-adrenal (HPA) axis, or secondary, caused by defects outside the HPA axis, usually results in adrenal insufficiency, which requires lifelong daily replacement of corticosteroids. However, this kind of therapy is far from ideal as physiological demand for steroids varies considerably throughout the day and increases during periods of stress. The development of alternative curative strategies is therefore needed. In this review, we describe the latest technologies aimed at either isolating or generating de novo cells that could be used for novel, regenerative medicine application in the adrenocortical field.
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