期刊
FRONTIERS IN ENDOCRINOLOGY
卷 5, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fendo.2014.00186
关键词
podocyte; diabetic nephropathy; saturated and monounsaturated free fatty acids; lipid metabolism; lipotoxicity; endoplasmic reticulum stress; beta-oxidation
资金
- Swiss Foundation for Grants in Biology and Medicine Fellowship [P3SMP3_151739/1]
- Swiss National Science Foundation [31003A-119974, 31003A-144112/1]
- Swiss Diabetes Foundation
- Fondation Sana, Switzerland
Podocyte injury and loss critically contribute to the pathogenesis of proteinuric kidney diseases including diabetic nephropathy. Deregulated lipid metabolism with disturbed free fatty acid (FFA) metabolism is a characteristic of metabolically unhealthy obesity and type 2 diabetes and likely contributes to end-stage kidney disease irrespective of the underlying kidney disease. In the current review, we summarize recent findings related to FFAs and altered renal FFA metabolism with a special focus on podocytes. We will outline the opposing effects of saturated and monounsaturated FFAs and a particular emphasis will be given to the underlying molecular mechanisms involving insulin resistance and endoplasmic reticulum homeostasis. Finally, recent data suggesting a critical role of renal FFA metabolism to adapt to an altered lipid environment will be discussed.
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