期刊
CANCER MANAGEMENT AND RESEARCH
卷 10, 期 -, 页码 2429-2437出版社
DOVE MEDICAL PRESS LTD
DOI: 10.2147/CMAR.S164675
关键词
vasculogenic mimicry; mechanisms; molecular imaging; clinical significance; target therapy
类别
资金
- National Natural Science Foundation of China [81372436, 81773230]
- Science and Technology Innovative Research Group of Zhengzhou city [121PCXTD524]
- Joint Research Funds of Henan province
- [201201009]
Vasculogenic mimicry (VM) describes the process utilized by highly aggressive cancer cells to generate vascular-like structures without the presence of endothelial cells. VM has been vividly described in various tumors and participates in cancer progression dissemination and metastasis. Diverse molecular mechanisms and signaling pathways are involved in VM formation. Furthermore, the patterning characteristics of VM, detected with molecular imaging, are being investigated for use as a tool to aid clinical practice. This review explores the most recent studies investigating the role of VM in tumor induction. Indeed, the recognition of these advances will increasingly affect the development of novel therapeutic target strategies for VM in human cancer.
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