期刊
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
卷 2, 期 1, 页码 12-21出版社
WILEY
DOI: 10.1002/acn3.136
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资金
- NCI NIH HHS [R01 CA159178] Funding Source: Medline
- NHLBI NIH HHS [R01 HL115828, R01 HL117888] Funding Source: Medline
- NIA NIH HHS [R01 AG034852] Funding Source: Medline
- NIMH NIH HHS [R01 MH080636] Funding Source: Medline
- NINDS NIH HHS [U10 NS077271, R01 NS043209, R25 NS080949] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [R01CA159178] Funding Source: NIH RePORTER
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL115828, R01HL117888] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH080636] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS043209, R25NS080949, U10NS077271] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [R01AG034852] Funding Source: NIH RePORTER
Objective: Brain involvement is a serious complication of HIV infection. The earliest changes in the brain, which represents an anatomic site for viral persistence, are largely unknown. Methods: This investigation used quantitative Magnetic Resonance methodologies, including high resolution and diffusion tensor (DTI) imaging, to evaluate the brain in 15 HIV and 20 seronegative subjects. All HIV subjects were antibody nonreactive with assay-estimated infection duration of less than 100 days. Results: Brain volumetric analysis revealed reduced parenchyma with enlargement of the third ventricle and brainstem. DTI quantified loss of white matter integrity in the corpus callosum and diffusion alterations in caudate. Cognitive differences were indicated in psychomotor speed and visual recall. There were no differences between antiretroviral-initiated and naive HIV subgroups. Interpretation: These findings, quantified within 100 days of infection, shed light on the earliest brain changes in HIV infection. Onset of neural injury may date to initial viral invasion and the transient early period of unchecked viremia and marked immunosuppression of the seroconversion period.
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