期刊
FRONTIERS IN CHEMISTRY
卷 6, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fchem.2018.00394
关键词
marine-derived; fungus; Talaromyces; talaropeptide; NRPS; linear peptide; secondary metabolite; natural product
资金
- University of Queensland
- Institute for Molecular Bioscience
- Australian Institute for Bioengineering and Nanotechnology
An Australian marine tunicate-derived fungus, Talaromyces sp. CMB-TU011 was subjected to a program of analytical microbioreactor (MATRIX) cultivations, supported by UHPLC-QTOF profiling, to reveal conditions for producing a new class of extensively N-methylated 11-12 residue linear peptides, talaropeptides A-D (2 5). The structures for 2 5, inclusive of absolute configurations, were determined by a combination of detailed spectroscopic and chemical (e.g., C-3 and C-18 Marfey's) analyses. We report on the biological properties of 2 5, including plasma stability, as well as antibacterial, antifungal and cell cytotoxicity. The talaropeptide mega non-ribosomal peptide synthetase (NRPS) is described, as second only in size to that for the fungus-derived immunosuppressant cyclosporine (an 11-residue extensively N-methylated cyclic peptide).
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