期刊
FRONTIERS IN CHEMISTRY
卷 6, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fchem.2018.00360
关键词
nanotechnology; nanomedicine; nanomaterials; pharmaceutical development; nanotoxicology
资金
- Fundacao para a Ciencia e a Tecnologia (FCT) [POCI-01-0145-FEDER-016648, PEst-UID/NEU/04539/2013, POCI-01-0145-FEDER-007440]
- FCT [PEstOE/QUI/UI0313/2014, POCI-01-0145-FEDER-007630]
- [UID/QUI/50006/2013-LAQV/REQUIMTE]
Several scientific areas have benefited significantly from the introduction of nanotechnology and the respective evolution. This is especially noteworthy in the development of new drug substances and products. This review focuses on the introduction of nanomedicines in the pharmaceutical market, and all the controversy associated to basic concepts related to these nanosystems, and the numerous methodologies applied for enhanced knowledge. Due to the properties conferred by the nanoscale, the challenges for nanotechnology implementation, specifically in the pharmaceutical development of new drug products and respective regulatory issues are critically discussed, mainly focused on the European Union context. Finally, issues pertaining to the current applications and future developments are presented.
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