期刊
CLINICAL EPIDEMIOLOGY
卷 6, 期 -, 页码 169-182出版社
DOVE MEDICAL PRESS LTD
DOI: 10.2147/CLEP.S38850
关键词
cryptococcosis; HIV; immunosuppression; antifungal therapy; immune reconstitution inflammatory syndrome; antiretroviral therapy
资金
- Wellcome Trust [100890] Funding Source: Medline
Cryptococcal meningitis causes morbidity and mortality worldwide. The burden of disease is greatest in middle- and low-income countries with a high incidence of human immunodeficiency virus (HIV) infection. Patients taking immunosuppressive drugs and some immunocompetent hosts are also at risk. Treatment of cryptococcal meningitis consists of three phases: induction, consolidation, and maintenance. Effective induction therapy requires potent fungicidal drugs (amphotericin B and flucytosine), which are often unavailable in low-resource, high-endemicity settings. As a consequence, mortality is unacceptably high. Wider access to effective treatment is urgently required to improve outcomes. For human immunodeficiency virus-infected patients, judicious management of asymptomatic cryptococcal antigenemia and appropriately timed introduction of antiretroviral therapy are important.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据