期刊
CELL SYSTEMS
卷 7, 期 1, 页码 5-16出版社
CELL PRESS
DOI: 10.1016/j.cels.2018.06.008
关键词
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资金
- BBSRC LIDo Doctoral Training Partnership
- UCL CoMPLEX Centre for Doctoral Training
- NIH R00 [CA197649]
- DoD Era of Hope Award [BC160541]
- Wellcome Trust Research Career Development Fellowship [097319/Z/11/Z]
Recent advances in synthetic biology and biological system engineering have allowed the design and construction of engineered live biotherapeutics targeting a range of human clinical applications. In this review, we outline how systems approaches have been used to move from simple constitutive systems, where a single therapeutic molecule is expressed, to systems that incorporate sensing of the in vivo environment, feedback, computation, and biocontainment. We outline examples where each of these capabilities are achieved in different human disorders, including cancer, inflammation, and metabolic disease, in a number of environments, including the gastrointestinal tract, the liver, and the oral cavity. Throughout, we highlight the challenges of developing microbial therapeutics that are both sensitive and specific. Finally, we discuss how these systems are leading to the realization of engineered live biotherapeutics in the clinic.
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