期刊
MATERIALS & DESIGN
卷 87, 期 -, 页码 17-24出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.matdes.2015.08.004
关键词
Hydroxylapatite/zinc oxide; Mesoporous nanofibers; Electrospinning technique; Antimicrobial activity
资金
- National Natural Science Foundation of China [31171788]
The aim of this study is to develop antimicrobial mesoporous hydroxylapatite/zinc oxide (meso-HA/ZnO) nanofibers from polyvinyl alcohol/hydroxylapatite/zinc acetate (PVA/HA/Zn(OAc)(2)) electrospun nanofibers by calcination process. The antibacterial activities of meso-HA/ZnO nanofibers towards Staphylococcus aureus (S. aureus, ATCC6538) and Escherichia coli (E. coli, 8099) were evaluated. The meso-HA/ZnO nanofibers were composed of hexagonal HA and wurtzite ZnO phases. The representative meso-HA/ZnO nanofibers with ZnO/HA ratio at 1:5 showed a wormhole-like shape, main pore diameter around 25 nm and specific surface area at 24.81 m(2)/g. The inhibition efficiency of meso-HA/ZnO nanofibers increased with the increase of ZnO/HA ratio, however, S. aureus was more sensitive to meso-HA/ZnO nanofibers than E. coli. The meso-HA/ZnO nanofibers with ZnO/HA ratio at 1:10 exhibited effective antibacterial activity towards S. aureus, whereas, the ZnO/HA ratio was raised up to 1:5 towards E. coli. The experimental results suggested that the meso-HA/ZnO nanofibers might have potential as an antimicrobial activity material in biomaterial applications. (C) 2015 Elsevier Ltd. All rights reserved.
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