期刊
RESEARCH SYNTHESIS METHODS
卷 4, 期 1, 页码 12-25出版社
WILEY
DOI: 10.1002/jrsm.1056
关键词
non-randomized studies; study design; bias; systematic reviews
资金
- Agency for Healthcare Quality and Research
- Cochrane Collaboration Discretionary Fund
- Medical Research Council [U105285807]
- Scottish Government Executive Health Department
- U.K. National Institute for Health Research Bristol Cardiovascular Biomedical Research Unit
- Chief Scientist Office [HSRU1] Funding Source: researchfish
- Medical Research Council [UD99999927, MC_U105285807] Funding Source: researchfish
- MRC [MC_U105285807] Funding Source: UKRI
Non-randomized studies may provide valuable evidence on the effects of interventions. They are the main source of evidence on the intended effects of some types of interventions and often provide the only evidence about the effects of interventions on long-term outcomes, rare events or adverse effects. Therefore, systematic reviews on the effects of interventions may include various types of non-randomized studies. In this second paper in a series, we address how review authors might articulate the particular non-randomized study designs they will include and how they might evaluate, in general terms, the extent to which a particular non-randomized study is at risk of important biases. We offer guidance for describing and classifying different non-randomized designs based on specific features of the studies in place of using non-informative study design labels. We also suggest criteria to consider when deciding whether to include non-randomized studies. We conclude that a taxonomy of study designs based on study design features is needed. Review authors need new tools specifically to assess the risk of bias for some non-randomized designs that involve a different inferential logic compared with parallel group trials. Copyright (C) 2012 John Wiley & Sons, Ltd.
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