期刊
REDOX BIOLOGY
卷 19, 期 -, 页码 158-165出版社
ELSEVIER
DOI: 10.1016/j.redox.2018.08.016
关键词
RPL10; ROS; Mitochondria; Regulation; Pancreatic cancer
资金
- 111 Project from the Ministry of Education of China
- State Administration of Foreign Export Affairs of China [111-2-07]
- National Science Foundation of China [91229116]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
Tumorigenesis is commonly known as a complicated process, in which reactive oxygen species (ROS) plays a critical role to involve in signal transduction, metabolism, cell proliferation and differentiation. Previously, ribosomal protein L10 (RPL10) was suggested to possess extra-ribosomal functions in pancreatic cancer cells in addition to being proposed as a tumor suppressor or transcription co-regulator. To better understand the relationship between RPL10 and tumorigenic potential in pancreatic cancer cells, chromatin immunoprecipitation sequencing reveals that RPL10 is unlikely to be a transcription factor without a specific binding motif for gene transcription. Additionally, transcriptome analysis indicates that RPL10 could regulate the expression of proteins related to ROS production. Moreover, RPL10 in mitochondria is closely associated with the regulation of ROS level by affecting Complex I activity and the subsequent events. Together, the present study suggests that the regulation of ROS level by mitochondrial RPL10 is one of the major extra-ribosomal functions in pancreatic cancer cells, which could be used as an indicator for the tumorigenesis of pancreatic cancer.
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