期刊
REDOX BIOLOGY
卷 1, 期 1, 页码 319-331出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.redox.2013.04.001
关键词
4-hydroxynonenal; Vascular biology; Endothelial cells; Vascular smooth muscle cells; Redox signaling; Nrf2
资金
- Heart Research UK
- British Heart Foundation
- Henry Smith Charity
- Great Britain Sasakawa Foundation
- British Heart Foundation [PG/13/1/29801] Funding Source: researchfish
4-hydroxynonenal (HNE) is a lipid hydroperoxide end product formed from the oxidation of n-6 polyunsaturated fatty acids. The relative abundance of HNE within the vasculature is dependent not only on the rate of lipid peroxidation and HNE synthesis but also on the removal of HNE adducts by phase II metabolic pathways such as glutathione-S-transferases. Depending on its relative concentration, HNE can induce a range of hormetic effects in vascular endothelial and smooth muscle cells, including kinase activation, proliferation, induction of phase II enzymes and in high doses inactivation of enzymatic processes and apoptosis. HNE also plays an important role in the pathogenesis of vascular diseases such as atherosclerosis, diabetes, neurodegenerative disorders and in utero diseases such as pre-eclampsia. This review examines the known production, metabolism and consequences of HNE synthesis within vascular endothelial and smooth muscle cells, highlighting alterations in mitochondrial and endoplasmic reticulum function and their association with various vascular pathologies. (C) 2013 The Authors. Published by Elsevier By. Open access under CC BY-NC-ND license.
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