期刊
PROBIOTICS AND ANTIMICROBIAL PROTEINS
卷 1, 期 1, 页码 67-74出版社
SPRINGER
DOI: 10.1007/s12602-008-9003-6
关键词
Probiotics; Lactocin 160; Bacterial vaginosis; Bacteriocin; Mode of action
资金
- NIH [NCCAM NIH R21AT002897-01]
- NATIONAL CENTER FOR COMPLEMENTARY &ALTERNATIVE MEDICINE [R21AT002897] Funding Source: NIH RePORTER
Bacterial vaginosis (BV) is a commonly occurring vaginal infection that is associated with a variety of serious risks related to the reproductive health of women. Conventional antibiotic treatment for this condition is frequently ineffective because the antibiotics tend to inhibit healthy vaginal microflora along with the pathogens. Lactocin 160, a bacteriocin produced by healthy vaginal lactobacilli, is a promising alternative to antibiotics; this compound specifically inhibits the BV-associated vaginal pathogens such as Gardnerella vaginalis and Prevotella bivia without affecting the healthy microflora. This study investigates the molecular mechanism of action for lactocin 160 and reveals that this compound targets the cytoplasmic membrane of G. vaginalis, causing the efflux of ATP molecules and dissipation of the proton motive force.
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