期刊
CELL SYSTEMS
卷 1, 期 1, 页码 72-87出版社
CELL PRESS
DOI: 10.1016/j.cels.2015.01.001
关键词
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资金
- NIH [F31GM111053]
- Epigenomcs Core Facility at Weill Cornell Medical College
- Clinical and Translational Sciences Center (CTSC)
- Pinkerton Foundation
- Vallee Foundation
- WorldQuant Foundation
- Illumina
- Qiagen
- Indiegogo
- New York University Grand Challenge project, Microorganisms, Sewage, Health and Disease: Mapping the New York City Metagenome''
The panoply of microorganisms and other species present in our environment influence human health and disease, especially in cities, but have not been profiled with metagenomics at a city-wide scale. We sequenced DNA from surfaces across the entire New York City (NYC) subway system, the Gowanus Canal, and public parks. Nearly half of the DNA (48%) does not match any known organism; identified organisms spanned 1,688 bacterial, viral, archaeal, and eukaryotic taxa, which were enriched for genera associated with skin (e. g., Acinetobacter). Predicted ancestry of human DNA left on subway surfaces can recapitulate U. S. Census demographic data, and bacterial signatures can match a station's history, such as marine-associated bacteria in a hurricane-flooded station. This baseline metagenomic map of NYC could help long-term disease surveillance, bioterrorism threat mitigation, and health management in the built environment of cities.
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