期刊
CELL SYSTEMS
卷 1, 期 4, 页码 293-301出版社
CELL PRESS
DOI: 10.1016/j.cels.2015.09.007
关键词
-
资金
- National Health and Medical Research Council of Australia (NHMRC) [APP1062227]
- NHMRC
- Australian Heart Foundation Career Development Fellowship [1061435]
- Victorian Life Sciences Computation Initiative (VLSCI)
- University of Oulu
- Sigrid Juselius Foundation
- Academy of Finland [141136, 139, 635]
- Yrjo Jahnsson Foundation
- Emil Aaltonen Foundation
- Finnish Diabetes Research Foundation
- Finnish Foundation for Cardiovascular Research
- Oulu University Central Hospital Medical Fund
- Helsinki University Central Hospital Medical Fund
- Kuopio University Central Hospital Medical Fund
- Tampere University Central Hospital Medical Fund
- Turku University Central Hospital Medical Fund
- Paavo Nurmi Foundation
- Juho Vainio Foundation
- Finnish Cultural Foundation
- Finnish Funding Agency for Technology and Innovation
- Paulo Foundation
- Maud Kuistila Foundation
- Finnish Medical Foundation
- British Heart Foundation
- Wellcome Trust
- Medical Research Council, UK
- Academy of Finland (AKA) [141136, 141136] Funding Source: Academy of Finland (AKA)
- Novo Nordisk Fonden [NNF15OC0015998] Funding Source: researchfish
The biomarker glycoprotein acetylation (GlycA) has been shown to predict risk of cardiovascular disease and all-cause mortality. Here, we characterize biological processes associated with GlycA by leveraging population-based omics data and health records from > 10,000 individuals. Our analyses show that GlycA levels are chronic within individuals for up to a decade. In apparently healthy individuals, elevated GlycA corresponded to elevation of myriad inflammatory cytokines, as well as a gene coexpression network indicative of increased neutrophil activity, suggesting that individuals with high GlycA may be in a state of chronic inflammatory response. Accordingly, analysis of infection-related hospitalization and death records showed that increased GlycA increased long-term risk of severe non-localized and respiratory infections, particularly septicaemia and pneumonia. In total, our work demonstrates that GlycA is a biomarker for chronic inflammation, neutrophil activity, and risk of future severe infection. It also illustrates the utility of leveraging multilayered omics data and health records to elucidate the molecular and cellular processes associated with biomarkers.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据