期刊
出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.preghy.2010.10.007
关键词
Angiogenesis; Hypertension; Glomerular endotheliosis; VEGF; Endoglin
资金
- Clinical Scientist Award from the Burroughs Wellcome Fund
- American Heart Association
Preeclampsia is a major cause of maternal and fetal morbidity and mortality worldwide, however, its etiology remains unclear. Abnormal placental angiogenesis during pregnancy resulting from high levels of anti-angiogenic factors, soluble Flt1 (sFlt1) and soluble endoglin (sEng) has been implicated in preeclampsia pathogenesis. Accumulating evidence also points to a role for these anti-angiogenic proteins as serum biomarkers for the clinical diagnosis and prediction of preeclampsia. Uncovering the mechanisms of altered angiogenic factors in preeclampsia may also provide insights into novel preventive and therapeutic options. (C) International Society for the Study of Hypertension in Pregnancy. Published by Elsevier B.V. All rights reserved.
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