期刊
ORGANIC CHEMISTRY FRONTIERS
卷 1, 期 5, 页码 458-463出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4qo00052h
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资金
- Ministerio de Economia y Competitividad, MINECO [CTQ2012-33272-BQU]
- Comunidad Autonoma de Madrid
The Hantzsch-type sequential three-component reaction under high-speed vibration milling conditions between 4-methyl-3-oxo-N-phenylpentanamide, tert-butyl 2-1(4R,6R)-6-(2-aminoethyl)-2,2-dimethyl-1,3-dioxan-4-yll-acetate and 1-14-ffuoropheny0-2-iodo-2-phenylethanone in the presence of ytterbium triflate and silver nitrate, followed by hydrolytic deprotection/lactonization, afforded atorvastatin lactone in 38% overall yield, thus providing ready access to the top-selling antihyperlipidemic drug atorvastatin calcium.
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