期刊
OPEN CHEMISTRY
卷 16, 期 1, 页码 882-889出版社
DE GRUYTER POLAND SP ZOO
DOI: 10.1515/chem-2018-0091
关键词
Corylifolinin; Antibacterial mechanism; Scanning electron microscopy; Bacterial membrane and wall permeability
资金
- Henan Province University Science and Technology Innovation Team [16IRTSTHN019]
- Kaifeng City Science and Technology Innovation Talent [1509010]
- National Cooperation Project of Henan Province [2015GH12]
Effective antibacterial activity against Gram-positive bacteria isolated in clinical strains was exhibited when corylifolinin was tested using the Disc diffusion method (K-B method). Minimum inhibitory concentration (MIC) of corylifolinin against Staphylococcus aureus (SA), Methcillin-resistant Staphylococcus aureus (MRSA) and extended spectrum beta-lactamases Staphylococcus aureus (ESBLs-SA) were 0.078, 0.156 and 0.078 mg/mL, respectively. The minimum bactericide concentrations (MBCs) were 0.156, 0.156 and 0.078 mg/mL respectively. Scanning electron microscopy (SEM), alkaline phosphatase (AKP) and bacterial extracellular protein leakage were used to investigate the antibacterial mechanism of corylifolinin. After adding corylifolinin at the MBC level, there were obvious changes to the Staphylococcus aureus of bacteria cells. Both MIC level and MBC levels of corylifolinin led to the leakage of AKP and bacterial extracellular protein.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据