期刊
CENTRAL EUROPEAN JOURNAL OF CHEMISTRY
卷 10, 期 5, 页码 1459-1463出版社
SCIENDO
DOI: 10.2478/s11532-012-0091-5
关键词
High-performance liquid chromatography; Core-shell (or fused core) column; Parabens; Hygiene wipes
The first HPLC method for the separation of three paraben preservatives (methyl-, ethyl- and propyl parabens) using a core-shell analytical column is reported in this study. The separation was completed in less than 8 min at a low flow rate of 0.4 mL min(-1) and an isocratic mobile phase containing 20% acetonitrile as organic modifier. The backpressure was < 200 bar in all cases, enabling the usage of conventional HPLC equipment. The proposed analytical procedure was validated for linearity (0.5-20 A mu g L-1), limits of detection (15-43 A mu g L-1) and quantification (50-142 A mu g L-1), selectivity, within day (1.3-1.5%) and day-to-day (3.4-4.6%) precision and accuracy. The proposed method has been applied to the determination of the selected paraben preservatives in commercially available hygiene wipes. The mean percent recoveries were found to be in the range of 98.0-98.4%.
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