期刊
CENTRAL EUROPEAN JOURNAL OF CHEMISTRY
卷 6, 期 4, 页码 562-568出版社
VERSITA
DOI: 10.2478/s11532-008-0064-x
关键词
Antifungal; Biginelli compounds; Boron; 3,4-dihydropyrimidin-2(1H)-(thio)ones; Monastrol
资金
- Canada Research Chairs Program, the Canadian Foundation for Innovation/Atlantic Innovation Fund
- Merck Frosst Canada and Co
The addition of formylphenylboronic acid derivatives to thiourea and ethyl acetoacetate proceeds in the presence of an additional Lewis acid catalyst to give the corresponding 3,4-dihydropyrimidin-2(1H)-(thio)ones (Biginelli products) in moderate yield. Compounds were tested for antifungal activity against pure cultures of Aspergillus niger, Aspergillus flavus, Candida albicans and Saccharomyces cerevisiae but, unfortunately, none showed any appreciable activity.
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