期刊
ONCOIMMUNOLOGY
卷 3, 期 11, 页码 -出版社
LANDES BIOSCIENCE
DOI: 10.4161/21624011.2014.970027
关键词
adoptive cell therapy; cancer; chimeric antigen receptor T cells; immune checkpoint molecules; tumor microenvironment
资金
- NCI NIH HHS [K08 CA163941] Funding Source: Medline
Chimeric antigen receptor (CAR) modified T cells have shown early promise in hematological malignancies. However, in solid malignancies CAR T cells must overcome a distinct immunosuppressive microenvironment which may compromise their capacity
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