Innate γδT17 cells convert cancer-elicited inflammation into immunosuppression through myeloid-derived suppressor cells

Chronic inflammation has been linked to cancer development and metastasis. We have recently demonstrated that gamma delta T cells are the major cellular source of IL-17 (gamma delta T17) and accumulation of gamma delta T17 cells correlates with human colorectal cancer progression through recruitment and expansion of myeloid-derived suppressor cells, thus converting tumor-elicited inflammation into immunosuppression.