期刊
ONCOIMMUNOLOGY
卷 3, 期 9, 页码 -出版社
LANDES BIOSCIENCE
DOI: 10.4161/21624011.2014.954925
关键词
abscopal effect; alpha emitters; cancer; immunogenic cell death; ionizing radiation; RIT
Radioimmunotherapy aims to deliver radiation directly to cancer cells by means of a tumor specific vector coupled to a radionuclide. Alpha radionuclides are very potent agents to treat disseminated cancer and metastasis. We have demonstrated that alpha radiation can also induce immunogenic cell death, reinforcing interest in their clinical development.
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